Crystal structures and Hirshfeld surfaces of two 1,3-benzoxathiol-2-one derivatives

Acknowledgements We thank the EPSRC National Crystallography Service (University of Southampton) for the X-ray data collections.Peer reviewedPublisher PD

tert-Butyl N-[3-hy­droxy-1-phenyl-4-(pyrimidin-2-ylsulfan­yl)butan-2-yl]carbamate monohydrate

In the title hydrate, C19H25N3O3S·H2O, the configuration at each chiral centre in the organic mol­ecule is S, with the hy­droxy and carbamate substituents being anti [O—C—C—N torsion angle = −179.3 (3)°]. The thio­pyrimidyl and carbamate residues lie to one side of the pseudo-mirror plane defined by the C5S backbone of the mol­ecule; this plane approximately bis­ects the benzene ring at the 1- and 4-C atoms. The dihedral angle formed between the terminal rings is 5.06 (18)°. In the crystal, supra­molecular tubes aligned along the b axis are found: these are sustained by a combination of O—H⋯O, O—H⋯N and N—H⋯O hydrogen bonds

N-{(2S)-3-Hy­droxy-4-[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]-1-phenyl-2-but­yl}-4-methyl­benzene­sulfonamide

The thia­diazoyl and sulfonyl-benzene rings in the title compound, C20H23N3O3S3, are aligned to the same side of the mol­ecule, forming a twisted ‘U’ shape [dihedral angle = 77.6 (5)°]. The benzyl-benzene ring is orientated in the opposite direction from the mol­ecule but projects approximately along the same axis as the other rings [dihedral angle between benzene rings = 28.2 (5)°] so that, overall, the mol­ecule has a flattened shape. The hy­droxy and amine groups are almost syn which enables the formation of inter­molecular hy­droxy-OH⋯N(thia­diazo­yl) and amine-H⋯O(sulfon­yl) hydrogen bonds leading to a supra­molecular chain aligned along the a axis

Four substituted benzohydrazides: hydrogen-bonded structures in one, two and three dimensions

The molecules of 2,6-dichloro-benzohydrazide, C7H6Cl2N2O, are linked into simple chains by a single N-H center dot center dot center dot O hydrogen bond, while in the isomeric compound 2,4-dichloro-benzo-hydrazide, the molecules are linked by N-H center dot center dot center dot N and N-H center dot center dot center dot O hydrogen bonds into complex sheets comprising an inner polar layer sandwiched between two non-polar layers. In 4-amino-2-chloro-benzohydrazide monohydrate, C7H8ClN3O center dot H2O, the components are linked into a three-dimensional framework by a combination of O-H center dot center dot center dot O, O-H center dot center dot center dot N, N-H center dot center dot center dot N and N-H center dot center dot center dot O hydrogen bonds, and in 2-nitro-benzohydrazide, C7H7N3O3, a three-dimensional framework is formed by a combination of N-H center dot center dot center dot N and N-H center dot center dot center dot O hydrogen bonds.</p